The Bloodstained Nun

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Aging and Alzheimer's disease: lessons from the Nun Study.

Sister Mary, the gold standard for the Nun Study, was a remarkable woman who had high cognitive test scores before her death at 101 years of age. What is more remarkable is that she maintained this high status despite having abundant neurofibrillary tangles and senile plaques, the classic lesions of Alzheimer's disease. Findings from Sister Mary and all 678 participants in the Nun Study may pro...

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Str Typing from Bloodstained Fabric without Dna Extraction

Whole blood from various individuals was spotted on 100% white cotton fabric. Once the bloodstains were dry, approximately 1 mm or less of the bloodstained thread was cut from each sample and placed in an autoclaved reaction tube containing either TE buffer or sterile distilled water. The tubes were then subjected to a simple preincubation period as described by the author previously (1). After...

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Healthy aging and dementia: findings from the Nun Study.

The Nun Study is a longitudinal study of 678 Catholic sisters 75 to 107 years of age who are members of the School Sisters of Notre Dame congregation. Data collected for this study include early and middle-life risk factors from the convent archives, annual cognitive and physical function evaluations during old age, and postmortem neuropathologic evaluations of the participants' brains. The cas...

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Healthy ageing in the Nun Study: definition and neuropathologic correlates.

BACKGROUND Although the concept of healthy ageing has stimulated considerable interest, no generally accepted definition has been developed nor has its biological basis been determined. OBJECTIVE To develop a definition of healthy ageing and investigate its association with longevity and neuropathology. METHODS Analyses were based on cognitive, physical, and post-mortem assessments from 199...

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ژورنال

عنوان ژورنال: The Iowa Review

سال: 2001

ISSN: 0021-065X,2330-0361

DOI: 10.17077/0021-065x.5450